Buscador de Tesis y publicaciones académicas

Bivalent aptamer-assisted CRISPR-Cas12a sensor for precise vancomycin therapeutic drug monitoring

Luqin Lv · Yizhuo Zhang · Yaxin Fan · Beining Guo · y 1 más

Therapeutic drug monitoring (TDM) of vancomycin (VAN) is critical for maximizing efficacy and minimizing toxicity, but conventional methods are constrained by high costs, slow turnaround times, and operational complexity. To address these limitations, we developed a novel Bivalent Aptamer-assisted CRISPR-Cas12a Sensor...

Balancing speed and separation: A high-throughput native mass spectrometry platform for screening complex bispecific antibody variants

Kyle, Spitler · Kateryna, Stepurska · Y Diana, Liu · Kevin, Legg · y 5 más

High-throughput liquid chromatography coupled to mass spectrometry (LC-MS) workflows are increasingly required to support the structural characterization of complex antibody formats such as multispecific (e.g. 2 + 1 and 1 + 1+1) and bispecific antibodies (bsAb) where misassembled product related variants pose significa...

Distribution networks providing reactive power as an ancillary service: Hierarchical integration of online feedback optimisation and fuzzy control

Manuel Schwenke · Jutta Hanson

The social embeddedness of learning: Social network formation and academic achievement in an undergraduate student community

Siyu Jiang · Christoph Stadtfeld

Background: Students play an active role in developing their social learning environment and peer relationships. Meanwhile, their academic behaviors are likely to be affected by their integration and individual positions in social networks. Despite the clear importance of social aspects on learning, the mechanisms shap...

The sweet spot of seeing: A categorization-based account of visual aesthetic pleasure

Dirk B. Walther

Aesthetic pleasure is shaped by many visual attributes, including prototypicality, fluency, complexity, symmetry, and self-relevance, but it is unclear why such diverse factors all influence liking. I propose that a major component of visual aesthetic pleasure is an epiphenomenon of categorization in the visual system,...

Enveloping algebras via motivic Hall algebras

Feng, Xinyi · Xu, Fan

We give a geometric realization of the whole universal enveloping algebras of Borcherds-Bozec algebras using quivers with loops via the motivic semi-derived Hall algebra approach.

Rich information markets: Designing feasible region bidding for optimal integration of DERs

Eslam Mofreh · Nilufar Neyestani · Phuong Nguyen · Koen Kok

This paper introduces Rich Information Markets (RIM), replacing scalar quantity-price bidding with multidimensional feasible region offers that preserve complete operational constraint sets. Four bid types are formulated: Capability-Constrained (CCB), Profile-Constrained (PCB), StateBased (SBB), and Storage Capability...

Notes on Chevalley groups and root category II: Compact Lie groups and representations

Li, Buyan · Xiao, Jie

This paper is a continuation of [5]. Using the root categories, we define the compact real forms of the complex semisimple Lie algebras, and maximal compact subgroups of the Chevalley groups over $\mathbb{C}$. In [7], Lusztig used the modified quantum group $\dot{\mathbf{U}}$ and its canonical basis to obtain the reduc...

Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial composition

Yoav, Uchitel · Dirk, Roggenbuck · Haim, Leibovitzh · Nathaniel Aviv, Cohen · y 4 más

Loss of tolerance to GP2, an antimicrobial immune-modulating component of intestinal cells and receptor on microfold cells, is associated with disease severity in Crohn's disease (CD). However, the role of GP2 in inflammatory bowel diseases remains poorly understood. This study aimed to evaluate fecal GP2 levels in pat...

A multi-well axon array device for evaluation of stimulus responses on human sensory neural spheroid-derived axon fascicles

Atsushi, Saito · Eiko, Yoshida · Satoshi, Nakasono

Understanding the response of sensory neurons involved in pain perception to external stimuli is crucial for developing chronic pain treatments and determining pain thresholds. In the field of drug discovery, cultured neurons derived from human induced pluripotent stem cells (hiPSCs) are used to evaluate pain perceptio...