Buscador de Tesis y publicaciones académicas

Molecular autopsy identifies the NaV1.5 p.Leu96Pro variant causing sodium current loss-of-function in unexplained sudden cardiac death

Albert Rigat Pujolas · Rebecca Martínez-Moreno · David Carreras · Yajaira Alvarado-Cervantes · y 4 más

Molecular autopsy can identify candidate variants in unexplained sudden cardiac death (SUD), but functional evidence is often required to support pathogenic interpretation and family risk assessment. Here, we investigated the functional consequences of the SCN5A c.287 T > C (NaV1.5_p.Leu96Pro) variant, identified in a...

Assessing the static liquefaction potential in earth dams using the bifurcation domain concept in numerical workflows

Chi, Fengdong · Veylon, Guillaume · Wautier, Antoine

Multi-scale Multi-techniques investigations of Li-ion batteries: towards a European Battery Hub

Sandrine LYONNARD · LAURENCE CROGUENNEC · Sergey YAROSLAVTSEV · Lorenzo STIEVANO · y 4 más

In this science-driven Long-Term proposal, we propose a 3-years multi-beamline program tackling grand challenges for actual, emerging and future battery technologies. We will deploy advanced methodologies for accelerating research by setting new cooperation modes for multi-techniques multi-scale studies. Three chemistr...

Refining the use of vanadium and uranium as paleoredox proxies by examining sediments from the Baltic Sea

Ashley MARTIN · Elena BAZARKINA · Bojidar MANDJOUKOV

The Baltic Sea is largely anoxic and sulfidic at depth but periodically oxygenated by the inflow of oxic seawater from the North Sea. This present an ideal natural laboratory to develop the application of the uranium (U) and vanadium (V) ‘paleoredox proxies’, which rely on interpreting the abundance and isotopic compos...

Characterization of Green's function of discrete Schrödinger operator on a finite graph by its spanning subgraphs

Yusuke Higuchi · Etsuo Segawa

The Green's function of the discrete Schödinger operator on a finite graph is considered. This setting reproduces Laplacian and signless Laplacian by adjusting appropriate potentials. We show two ways of the expression for the Green's function by using graph structures. The first way is based on the factor of the graph...

Investigating Drug Encapsulation in Hierarchical Vaterite Particles Using Coherent X-ray Diffraction Imaging

Jessica ZEMAN · Yuriy CHUSHKIN · Joe STICKLAND · Seniz UCAR · y 4 más

Mineral particles are amongst the most commonly used drug delivery vehicles for cost-effective, biocompatible and biodegradable drug delivery solutions. The vaterite form of CaCO3 has emerged as an ideal system due to its structural versatility, biocompatibility, mechanical stability and pH responsive biodegradability....

Time-resolved serial oscillation crystallography applied to light-driven DNA repair

Nicolas CARAMELLO · Manuel MAESTRE-REYNA · Yuhei HOSOKAWA · Wei-Ting LIN · y 4 más

Members of the photolyase-cryptochrome superfamily (PCSF) utilise transient electron transfer (ET) for diverse reactions including light-driven DNA repair, and photo- and magnetoreception. As such, they represent a ubiquitous and central class of enzymes which has attracted an enormous amount of attention. Over the las...

Understanding the Doping Modification of High-Ni and Low-Co Oxide Materials by probing the structural and chemical properties using X-ray p

Peter CLOETENS · Zhichen XUE

This necessitates the localized probes to comprehensively investigate the structural and chemical evolution of electrodes during battery cycling, revealing how the complex interplay among void formation, interphase growth affects battery properties, such as cycle life and safety. Herein, we propose to combine hard x-ra...

CRISPR-Cas9 mediated adiA knockout in Hafnia paralvei: Implications for agmatine production and acid stress survival in a fermented dairy matrix

Angel Casado · Sandra M. Wellner · Alejandro Quirós · Ana Herrero-Fresno · y 3 más

Agmatine, the product of the decarboxylation of arginine, catalysed by arginine decarboxylase (ADC), is a bioactive compound that functions as a neuromodulator and co-transmitter and has gained increasing attention in recent years due to its therapeutic potential, particularly for its neuroprotective properties. Member...

Designing new sustainable nanoformulations for plants and agriculture

Francesca RIPANTI (ORCID: 0000-0002-9505-740X) · Sara FALSINI · VERONICA BUTELLI · Mert ACAR · y 5 más

Environment protection is a major issue for sustainability and can be promoted by administering beneficial compounds to plants and soil. Most bioactive molecules are poorly soluble in water and need hydrophilic carriers to be assimilated1. Nanovectors ensure optimal performance with minimal quantities due to high surfa...