Buscador de Tesis y publicaciones académicas

From Framework to Practice: Evaluating the Uptake of Sensitivity Analyses in The National Institute for Health and Care Excellence Real-World External Control Arm Evidence

Leahy, Thomas P. · Keenan, Craig · Robertshaw, Emily · McStravick, Megan · y 3 más

Growing reliance on single-arm trials (SATs) is driving increased real-world external control arm (RW-ECA) use in health technology assessment submissions. However, concerns over residual confounding and unmeasured bias often limit acceptability. The National Institute for Health and Care Excellence (NICE) real-world e...

The influence of the Variscan belt collapse on the onset of the Paris Basin

Francesco Arboit · Alessandro Decarlis · Marta Gasparrini · Sveva Corrado · y 2 más

At the scale of the European peri–Tethyan basins, the Paris Basin is one of the largest intracratonic sedimentary repositories within the collapsing post-Variscan continental crust. However, the limited availability of petrochronological constraints on its late Carboniferous detritus has hindered the development of an...

Liquid-phase High-Pressure Synthesis of New Metal Silicide Electrocatalysts for H2 Production

Natalia TRESPALACIOS VILLALOBOS · Martin DEMOUCRON · Mohamed MEZOUAR · David PORTEHAULT · y 2 más

This proposal aims to investigate the Fe/Ni-Si system under high pressures (HP) to discover new materials for efficient H2 production via water splitting. While room pressure Ni/Fe silicides have shown remarkable electrocatalytic properties, our intention is to exploit the rich structural diversity of these materials u...

Noticed but not decisive: a randomised test of artificial intelligence in teaching materials

ELCIYAR, KEMAL · YILMAZ, MUHAMMED ENES

A unified low-rank ADI framework with shared linear solves for simultaneously solving multiple Lyapunov, Sylvester, and Riccati equations

Umair Zulfiqar · Zhong-Yi Huang · Qiu-Yan Song · Zhi-Yuan Gao

The alternating direction implicit (ADI) methods are computationally efficient and numerically effective tools for computing low-rank solutions of large-scale linear matrix equations. It is known in the literature that the low-rank ADI method for Lyapunov equations is a Petrov-Galerkin projection algorithm that implici...

The role of the gut-brain axis and polyphenolic compounds in glioblastoma

Bhavana Agnihotram · Iris Mutiu · Hannah Chiou · Kelly McGowen · y 1 más

Polyphenols are metabolites derived from plant-based sources studied in cancer research for their anti-inflammatory, antioxidant, and antiproliferative properties. While previous studies have focused more on their impact on gastrointestinal diseases like inflammatory bowel disease and malignancies such as colon cancer,...

Thermal equation of state and spin crossover of (Fe2+, Fe3+)-bearing Al-Phase D

Angelika ROSA · KATARZYNA MARIA SKRZYNSKA · Yungui LIU · Ilya KUPENKO · y 5 más

Hydrous silicate phase D is considered to be a potentially important carrier and reservoir in Earth’s deep interior. The experiments aim to investigate the crystal structural evolution, thermal equation of state, spin state of iron, and hydrogen bond configuration in (Fe2+, Fe3+)-bearing Al-Phase D utilizing the Single...

A sampling method based on highest density regions: Applications to surrogate models

Jocelyn Minini · Micha Wasem

This paper introduces a practical, one-shot design-of-experiments strategy for training surrogate models in the context of uncertainty quantification. Instead of drawing the experimental design according to the input distribution, which favours training points around its mode, we propose a heuristic method to sample un...

Structure of the VSV transcription machinery

Christiane RIEDEL (ORCID: 0000-0002-4349-996X) · Gregory EFFANTIN · Louis-Marie BLOYET

To transcribe and replicate their genome, mononegaviruses use a sophisticated RNA synthesis machinery made of a polymerase complex and a ribonucleoprotein template. Structural information on how these two components assemble to form a functional transcription complex is lacking. The objective is to decipher the molecul...

Beyond numbers: Spatial ability development through targeted training in Irish secondary level mathematics classrooms

Liam Maquet · Rónán Dunbar · Gavin Duffy · Sheryl Sorby · y 1 más

Research has consistently demonstrated a strong relationship between spatial ability and STEM achievement, with higher levels of spatial ability in early life linked to the attainment of advanced STEM degrees. With current reforms in Irish secondary level STEM subjects, questions remain as to how spatial ability develo...