Distinct molecular pathways regulated by activated AKT and YAP signaling during intrahepatic cholangiocarcinoma progression: Roles of AKT and YAP during iCCA.
Zhao J · Yang L · Qin Y · Zhang Y · y 18 más
Background & aims: Activated AKT and YAP signaling have been implicated in the pathogenesis of intrahepatic cholangiocarcinoma (iCCA), but their specific roles in tumor progression and regulation of the tumor microenvironment remain unclear. Methods: We developed two doxycycline-inducible iCCA mouse models, Akt/TRE-YAP...
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