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Trodimenzionalne stanične kulture razvile su se kao odgovor na ograničenja klasičnih dvodimenzionalnih kultura, koje ne mogu vjerno prikazati građu i ponašanje stanica u živom tkivu. Organoidi se najčešće uzgajaju iz embrionalnih, induciranih pluripotentnih i odraslih matičnih stanica, a tijekom rasta i diferencijacije...
matične stanicemedical engineeringorganoidiBasic Medical Sciences
Breast cancer is the leading malignancy among women in Croatia and worldwide. Surgical treatment remains the cornerstone of therapy for localized disease, despite advances in systemic therapy and other treatment modalities. Contemporary surgical techniques such as skin-sparing mastectomy (SSM) and skin and nipple-spari...
Sleep and the circadian rhythm are regulated by a complex interplay of neuroanatomically and neuroendocrinologically interconnected structures, with light serving as the most important external factor for synchronizing the internal biological clock. Intrinsically photosensitive retinal ganglion cells play a key role in...
Cerebral vasospasm is one of the most important complications of subarachnoid hemorrhage (SAH) and plays a significant role in the development of delayed cerebral ischemia and poor neurological outcomes in patients. It most commonly develops between the 3rd and 14th day after hemorrhage and occurs as a result of comple...
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the destruction of pancreatic β-cells and absolute insulin deficiency, whose treatment requires lifelong insulin replacement therapy. The clinical presentation includes polyuria, polydipsia, and polyphagia, while diabetic ketoacidosis (DKA) often...
Trudnoća je razdoblje izrazitih hormonskih, metaboličkih i hemodinamskih promjena koje utječu na gotovo sve organske sustave, a omogućuju prilagodbu organizma potrebama fetusa. Te promjene mogu otežati razlikovanje fizioloških promjena od patoloških stanja. Važna je pravilna interpretacija laboratorijskih nalaza kako s...
Renal cell carcinoma is one of the most lethal malignancies of the urinary system. During recent decades its incidence has increased, but also the trend of early detection of this disease while in earlier stages. Although surgery can be curative, approximately 40% of patients with an intermediate-high or high risk of r...
renal cell carcinomaRadiotherapy and Oncologyadjuvantno liječenjeadjuvant therapy
Melanoma is a malignant tumor of melanocytic origin with pronounced metastatic potential. Although early-stage disease is treated primarily by surgery, with a favorable prognosis, the development of distant metastases considerably worsens treatment outcomes. The most common metastatic sites include non-regional lymph n...
Objective: The aim of this study was to examine the relationship between body composition parameters measured by bioelectrical impedance analysis and physical activity levels, and to identify predictors of high physical activity in patients with inflammatory bowel disease on biological therapy. Materials and methods: A...
sastav tijelabody compositionbioelektrična impedancijainterna medicina
Laktacidoza povezana sa primjenom metformina (MALA) je rijetka, ali potencijalno životno ugrožavajuća komplikacija liječenja šećerne bolesti. Nastaje kao posljedica nakupljanja metformina zbog nemogućnosti njegovog izlučivanja putem bubrega, te posljedične neravnoteže između stvaranja i iskorištavanja laktata, te porem...
metabolic acidosisdiabetes mellitus type 2hemodialysisinterna medicina
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