Buscador de Tesis y publicaciones académicas

From genetic testing to prevention: an integrated clinical pathway for hereditary risk assessment in tubo-ovarian cancer

David Viveros-Carreño · Nathalia Mora-Soto · Isabel Beshar · Nuria Agustí · y 5 más

Hereditary tubo-ovarian cancer risk assessment has evolved from a BRCA1/2-centered consultation to an integrated prevention pathway that begins at diagnosis and extends to unaffected relatives. Germline testing is now justified for patients with epithelial tubo-ovarian cancer because actionable pathogenic variants are...

Modulation of ruminal fermentation and microbiome through natural additives derived from agricultural by-products

Vicente Diaz Avila · Venício Macedo Carvalho · Edinéia Bonin · Melina Aparecida Plastina Cardoso · y 5 más

AWaRe-aligned doxycycline-based bismuth quadruple therapy achieves high Helicobacter pylori eradication rates and supports antimicrobial stewardship

Giovanna Casadiego, Santiago · Ismael, de Jesús Yépez Barreto · Betty P, Morales · Fernando García Del, Risco

Helicobacter pylori infects a large proportion of the global population. The World Health Organization (WHO) developed the Access, Watch and Reserve (AWaRe) classification to promote rational antibiotic use and reduce antimicrobial resistance. The aim of this study was to evaluate the efficacy of a doxycycline-based bi...

EVENTO CIENTÍFICO CON COMPONENTE DE APROPIACIÓN SOCIAL DEL CONOCIMIENTO TEJIENDO SABERES: CONVERSATORIO Y ESPACIO DE CO-CREACIÓN TERRITORIAL

Acuña Reyes, Estefany Paola · Serje, David · Torres López, Natalia Paola · Arzuaga, Erika

Título original: TEJIENDO SABERES: CONVERSATORIO Y ESPACIO DE CO-CREACIÓN TERRITORIAL Subtítulo: Sistematización del evento científico con componente de Apropiación Social del Conocimiento y diálogo intercultural.

Comprehensive evaluation of AlphaFold/OpenFold prediction of experimentally unresolved proteins through novel metrics

Florencia R Díaz · Daniela Orschanski · Juan I Folco · Juana Espain Ceci · y 4 más

Abstract Predicting accurate protein structures is essential for understanding molecular mechanisms, interpreting the impact of sequence variation, and supporting translational applications ranging from drug discovery to clinical genomics. Recent advances in deep-learning–based predictors such as AlphaFold2, OpenFold,...

Experiences of families of surviving patients in critical care units: A grounded theory analysis

Yulieth María, Zabaleta Polo · Angela María, Henao-Castaño

Being a family member of a critically ill survivor often involves a process of familial and physical changes during recovery and rehabilitation at home.Understanding the experiences of families of patients discharged from the intensive care unit.A qualitative study using grounded theory, the constructivist approach of...

Successful control of double carbapenemase-producing Klebsiella pneumoniae (KPC-NDM) outbreak in a hospital in Colombia

Santiago Sánchez Pardo · Marcela Vargas Vargas · Nubia Esperanza Zea Cuadrado · Sonia Reyes Peña · y 1 más

Infections caused by Klebsiella pneumoniae producing the carbapenemases K. pneumoniae carbapenemase (KPC) and New Delhi metallo-β-lactamase (NDM) are a growing challenge in Latin America. These multi-drug-resistant strains have been associated with high morbidity and mortality rates. In Colombia, the spread of these in...

Deconstructing White Dot Syndromes–Multimodal Imaging in Uveitis (MUV) Taskforce: Report 11

ALESSANDRO INVERNIZZI · ANIRUDDHA AGARWAL · LEE M. JAMPOL · SRINIVAS R. SADDA · y 64 más

The term white dot syndromes (WDS) has historically grouped multiple non-infectious posterior uveitis (NIPU) entities based on a similar funduscopic appearance of "white dots." Despite decades of use, the clinical relevance of this umbrella terminology has been questioned. This perspective critically examines whether W...

A bilevel model and a column generation heuristic for the transit network design and frequency setting problem with capacity constraints

Daniel O. Martínez-Quezada · Cristián E. Cortés · Michel Gendreau · Antonio Mauttone

A mixed-methods study of methodological approaches in population-based cancer registries in the North and South

Tolentino-Rodriguez, Lisbeth · Luengo, Sara · Fakih, Mariam · Cortés Buelvas, Armando · y 12 más

Population-based cancer registries (PBCRs) are essential for cancer surveillance; reliable and comparable data depending on both methodological standards and operational organization. While international guidelines define core quality indicators, less is known about how governance structures and registry workflows infl...