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Height is a well-established risk factor for cancer development, with each 10cm increase in height correlating to a ~10% increase in cancer risk. There does not appear to be a simple explanation for this association, reflecting the genetic complexities of both height and cancer. Mendelian (single gene) syndromes have t...
UK BiobankVariant deleteriousness predictorsGrowth deficiency syndromesMeier-Gorlin syndrome
The software industry is continuously growing, and software source code quality is becoming more critical than ever. As a result, methodologies for software validation and verification are being developed, including Static Code Analysis (SCA) tools. SCA tools generate warnings for potential code quality violations, and...
Machine LearningLarge Language ModelsStatic Code Analysis ToolsContext-aware Classification
Breast cancer remains a major global health burden, and microcalcifications are an important feature frequently seen on mammograms. These microcalcifications occur in two distinct chemical forms, calcium oxalate and hydroxyapatite. However, only hydroxyapatite is potentially associated with malignancy. Conventional mam...
In Aotearoa New Zealand, pounamu (jade) remains the most significant taonga (treasure) for Māori, embodying mana (prestige), tradition and spirituality. During the late 19th century, a substantial number of pounamu artefacts were fossicked from archaeological sites, resulting in the loss of their original context and d...
SARS-CoV-2 also encodes many innate immune antagonist genes and is excellent at subverting the host immune response. Immune dysregulation leads to the development of both acute disease, as well as long term disease manifestations called post-acute sequelae of SARS-CoV-2 (PASC). To develop effective therapeutics for pat...
basic medicinemedical and health sciencesCoronavirusesCOVID-19
Superconducting quantum circuits are a leading hardware candidate for realizing a large-scale fault-tolerant quantum computer. However, scaling superconducting quantum computers will soon approach the physical limits imposed by their cryogenic operating environments. Consequently, interconnects between multiple process...
The consumption of alternative grains has been on the rise in the last couple of years due to their nutritional value, allergen-friendly properties, and sustainability. However, these crops are unable to match wheat flour functionality. Therefore, this dissertation attempts to understand which buckwheat and proso mille...
Building on this conceptual framing, the thesis investigates heat-flow and thermal performance through laboratory tests, Design Builder simulations, and field experiments. Laboratory studies isolate the effects of aeration, pigmentation, and water depth on thermal behaviour, demonstrating that aeration suppresses strat...
The Rayleigh-Taylor (RT) instability arises when a denser fluid is accelerated into a lighter fluid, which eventually transitions into a buoyancy-driven turbulent mixing layer. At sufficiently late times, simple dimensional arguments predict that the mixing-layer height grows self-similarly and quadratically with time....
Proteomic analysis revealed that, rather than directly interacting with the NGF/TrkA pathway, t-BG treatment significantly altered the expression of proteins associated with iron binding and regulation. These findings suggest that t-BG’s biological activity may be linked to iron homeostasis rather than classical neurot...
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