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Chemical modification of curcumin using polymer-metal-drug complexation leads to ~ 2.5 times enhancement in drug release in biological media at pH 5.0 and 7.4, as compared to only curcumin. The presence of curcumin shows up to ~ 9 times lesser osteosarcoma viability than that of the control after 11 days of cell cultur...
in vivo surgerynaturally derived biomoleculesmedical engineeringdrug delivery
Posttraumatic stress disorder (PTSD) and chronic pain (CP) are highly co-occurring conditions, characterised by poor treatment outcomes and shared mechanisms that exacerbate symptom severity and functional impairment. This randomised, waitlist-controlled trial evaluated the efficacy of a six-week heart rate variability...
Obesity and its associated disorders are some of the largest worldwide public health issues. Obesity rates continue to go up worldwide, and their increase correlates with an increase in portion size and increased consumption of a high fat high sugar diet (HFHSD). Both of these factors suggest that a disruption of gut-b...
There is a critical nursing shortage worldwide and newly licensed registered nurses (NLRN) are needed to fill this gap. Within the United States, there are approximately 150,000 NLRN graduated per year. Approximately one out of five NLRN (30,000) will leave the nursing field after the first year, and another 1/3 (20,00...
Pre-licensure nursing studentsmedical and health sciencesBurnoutNewly licensed registered nurses
Current neurobiological theories of sleep/wake regulation and neurobehavioral functioning during sleep loss do not account for trait-like, inter-individual and task-dependent differences. Neuroimaging evidence suggests that aspects of cognition may have dissociable neurological mechanisms which may underlie these task-...
Total sleep deprivationCircadian rhythmsocial sciencesNeurobehavioral functioning
The operation of buildings is a major source of greenhouse gas emissions, accounting for 27% of energy-related carbon dioxide emissions globally. There is large potential for reduction in these emissions through energy efficiency improvements and optimised operation of buildings.Models of building energy consumption ar...
other engineering and technologiesSolar gainengineering and technologyHidden Markov models
The overall hypothesis for this thesis is that miRNAs are altered during infection with Leishmania spp. that causes VL (L. donovani and L. infantum) and those miRNAs may have the ability to decrease the expression of pro-inflammatory genes, contributing to the systemic immune suppression seen in VL. This was investigat...
Exosomehealth sciencesmedical and health sciencesLeishmaniasis
Copositive matrices, first introduced by Theodore S. Motzkin in 1952, are generalizations of positive semidefinite matrices. A real symmetric matrix A ∈ Mn(R) is called copositive if xTAx ≥ 0 for all x ≥ 0. The study of copositivity has expanded into various areas of mathematics, including optimization, graph theory, a...
Copositive MatrixLinear AlgebraCopositive RangeNumerical Range
Findings challenge the GIM, which predicts that greater gender equality and increased empowerment lead to higher tobacco use among women. Instead, across all studies, higher educational attainment consistently emerged as a protective tobacco use factor. In one study, gender equality narratives did not elevate smoking r...
Cells generate highly dynamic branched F-actin structures which are found in different locations to facilitate specific cellular processes. For example, they are found at sites of endocytosis, phagocytosis, and at the leading edge of migrating cells. These densely arborized actin networks are assembled by the Arp2/3 co...
basic medicinemedical and health sciencesBiochemistry
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