Buscador de Tesis y publicaciones académicas

Hypertension in Colombia: First pharmacogenomic risk profile stratified by ancestry

Maria L. Ochoa-Elles · David A. Hernandez-Paez · Amileth Suarez-Causado

# htn-gwas ## Purpose This study explores the influence of genetic ancestry on PGx risk profile related to hypertension in Colombian populations. We assessed allele frequency differences between African- and European-ancestry groups and performed correlation analyses. This repository includes both the full dataset and...

Withdrawal versus continuation of guideline-directed medical therapy in heart failure with improved ejection fraction: a systematic review and meta-analysis

Juan Camilo Hernández Jaramillo · Juan Esteban Suárez Muñoz · María Cristina Oviedo Arroyo · María José Díaz Gutiérrez · y 1 más

Abstract Background Heart failure with improved ejection fraction (HFimpEF) is characterized by recovery of left ventricular systolic function after treatment for heart failure with reduced ejection fraction. The safety of withdrawing guideline-directed medical therapy (GDMT) after recovery remains uncertain. Objective...

Modeling Tay-Sachs Disease in Astrocyte-like Cells Reveals Significant Changes in the Transcriptomic Profile

Diego A. Suárez-García · Angela J. Espejo-Mojica · Carlos J. Alméciga-Díaz

Tay-Sachs disease is a rare genetic disorder characterized by the accumulation of GM2 ganglioside in neuronal lysosomes due to deficient β-hexosaminidase A (HexA) activity. Progressive GM2 storage leads to severe neurodegeneration, including developmental delay, motor weakness, seizures, ataxia, and early death, typica...

Cocoa by-products extracts suppress viral replication and oxidative stress in chikungunya virus-infected cells

Sandra Johanna Morantes · Luisa Fernanda Daza · Alejandro Cáceres · Luis Felipe Gutiérrez · y 3 más

Context Studies have demonstrated a correlation between oxidative stress and Chikungunya virus (CHIKV) replication, underscoring the potential of these biochemical interactions for developing novel antiviral therapies. Since cocoa ( Theobroma cacao L. ) by-products have exhibited potent antiviral and antioxidant proper...

Ventriculo-Arterial Coupling: Historical Foundations, Physiological Principles, and Clinical Relevance in Critical Care Hemodynamics

Buitrago, Camilo Andres Martínez · Murillo, Nancy Rocio Acosta

Ventriculo-arterial coupling describes the interaction between ventricular contractile performance and the arterial system, integrating end-systolic ventricular elastance, arterial elastance, stroke volume generation, and cardiovascular efficiency into a unified physiological framework. Although historically rooted in...

Hematocrit-to-Hemoglobin Ratio in Aneurysmal Subarachnoid Hemorrhage: A Prognostic Signal, but Not Yet a Surrogate for Blood Viscosity

María Claudia Niño · Darwin Cohen · Daniel Guerra · Brahyan Osorio · y 1 más

Prospective Study of Different Diagnostic Criteria for Catatonia and Delirium in Internal Medicine and Neurology Admissions

Natalia, Gutiérrez Ochoa · Juan Diego, Corzo Casadiego · Gabriela, Castresana Zúñiga · Carolina, Zapata · y 5 más

The authors prospectively examined the relationship between catatonia and delirium in consecutive hospital admissions. Potentially confounding neuropsychiatric conditions for catatonia symptoms were also assessed.In this cross-sectional study of 223 geriatric inpatients with or without delirium, the authors rated sympt...

Astrocyte-driven small vessel disease is an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer’s disease

Jessica Lisa Villalba-Moreno · Yassir El-Amri · Keun-Young Kim · Nelson David Villalba-Moreno · y 16 más

Abstract Cerebral Small vessel disease (cSVD) is a prevalent feature of Alzheimer’s disease (AD) pathology. Whether this pathology is a late consequence of amyloid and tau accumulation or an early, direct effect of PSEN1 dysfunction has remained unresolved. We found that it is more severe in familial AD (FAD) caused by...

Chronic Kidney Disease in Context: Detection and Severity Among Afro-Descendant Communities in Colombia

Karen Rocío Flórez · Karen Cecilia Flórez Lozano · Guirlessa Andrea De la Hoz Guerrero · Mariangel Mercado Utria · y 6 más

To examine how health insurance and access to care shape the detection of chronic kidney disease (CKD) and to assess determinants of CKD severity among Afro-descendant adults in the Colombian Caribbean. This was a cross-sectional study using community-based screening data and applying multivariable regression and media...

Mapping drivers of life expectancy change in Asia from 1990 to 2023

Jiseung Kang · Hyeon Jin Kim · Min Seo Kim · Jeofrey Bautista Abalos · y 196 más

Life expectancy is a key indicator of population health and an important guide for health policy1,2. Although Asia represents approximately 60% of the global population, studies of longitudinal trends in life expectancy and their underlying drivers across Asian countries remain limited, with most previous research focu...